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Horm Metab Res 1988; 20(5): 264-266
DOI: 10.1055/s-2007-1010811
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

The Involvement of Calmodulin in the Secretion of Calcitonin from the Porcine Thyroid Gland

S. K. Abbas, A. D. Care
  • Department of Animal Physiology and Nutrition, University of Leeds, Leeds, United Kingdom
Further Information

Publication History

1987

1987

Publication Date:
14 March 2008 (online)

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Summary

The effect of the calmodulin antagonist W7 has been studied in the pig in vivo by measuring directly the secretion rate of calcitonin (CT) in the thyroid venous blood after surgical isolation of the thyroid and subsequent perfusion of the gland in situ. Over the concentration range of W7 9-100 μmol/l in the perfusing plasma there was a significant increase in CT secretion rate associated with the addition of W7 to the perfusing blood. There was no significant change in the perfusing plasma calcium concentration. It is suggested that calmodulin plays an important role in calcium homeostasis within the porcine thyroid C-cell.

Key-Words

Calmodulin - Calcitonin - Pig - Thyroid