We have studied the effect of chronic noise stress (St) and ACTH administration (Ac)
affecting blood pressure and plasma corticosterone levels in male Wistar rats. Both
chronic treatments elicited an increas in plasma corticosterone and blood pressure
levels. The blood pressure increased from the first week of treatment period in St
and Ac rats and remained high 4 weeks after the end of the stress period. However,
blood pressure elevation decrease progressively during the first three weeks of post-treatment
in ACTH administrated rats. The rise of blood pressure levels was due to the effect
of chronic treatment. This was demonstrated by the absence of differences between
the two values of blood pressure measurement with and without daily treatment in both
St and Ac groups. Increased corticosterone levels decreased rapidly during the post-treatment
period in St and Ac rats. The results suggest a possible relationship between the
development of hypertension and the Hypothalamus-Hypophysis-adrenal (HHA) axis stimulation
in rats.
Corticosterone
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Blood Pressure
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Chronic Stress
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ACTH
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Noise
