Interrelation Between Glucose, Insulin, C-Peptide and 3-Hydroxybutyrate in Plasma and Amniotic Fluid in Last Trimester Diabetic Women Without Residual Betacell Function

Summary

The relationship between maternal plasma and amniotic fluid (AF) concentrations of glucose, insulin, C-peptide and 3-hydroxybutyrate (3-HB) was analysed between 45 to 140 minutes after a standardized breakfast in 8 type I diabetic women without residual betacell function and in 13 non-diabetic control women during the last trimester of gestation. AF levels of both glucose and C-peptide were slightly and AF insulin levels significantly (P < 0.05) elevated above normal in the diabetic women. 3-HB levels in plasma and in AF were significantly (P < 0.05) elevated in the diabetic group between 45 to 65 minutes after breakfast. AF insulin and glucose was significantly correlated in the diabetic group (r = 0.96, P < 0.05). During the 2 hour study period AF levels of glucose, insulin and C-peptide remained essentially unchanged in both groups of women. Changes in maternal plasma 3-HB concentrations seemed to be more rapidly reflected in AF.

Key-Words

Diabetic Pregnancy - Amniotic Fluid - Glucose - Insulin - C-Peptide - 3-HB