Using the forearm technique, muscular ketone body metabolism was investigated in 12
healthy volunteers during an i.v. infusion of lipid emulsions containing long chain
triglycerides (LCT) or a mixture of medium- and long chain triglycerides (MCT/LCT).
During the basal period, arterial concentrations and muscular extraction of β-hydroxybutyrate
and acetoacetate were linearly correlated as expected. This relationship was abolished
during the infusion of both lipid emulsions. In addition, fractional extraction rates
of ketone bodies were reduced. These changes were most probably mediated by elevated
levels of free fatty acids and triglycerides as well.
Forearm Technique
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Medium Chain Triglycerides
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Long Chain Triglycerides
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Muscular Ketone Extraction
