Subscribe to RSS
DOI: 10.1055/s-2007-1010872
© Georg Thieme Verlag, Stuttgart · New York
Dissociated Response of Aldosterone from Plasma Renin Activity During Prolonged Exercise Under Hypoxia
Publication History
1987
1987
Publication Date:
14 March 2008 (online)
![](https://www.thieme-connect.de/media/hmr/198808/lookinside/thumbnails/10.1055-s-2007-1010872-1.jpg)
Summary
6 healthy male subjects on a fixed salt-diet performed 1 hour ergocycle exercise at 65% of V̇O2 max in normoxic (N) and hypoxic (H) conditions. Blood samples were taken at intervals for estimations of plasma aldosterone (PAC), angiotensin converting enzyme (ACE), adrenocorticotrophic hormone (ACTH) and catecholamine concentrations. Plasma volume reductions with exercise were similar in N (4.3±1%) and H (4.0±1%). PRA response to exercise was increased by hypoxia while PAC and plasma catecholamine rose to a similar extent in both conditions. Increases in ACTH concentration occurred at the end of exercise but no difference was found between high and low altitudes. Plasma ACE remained unchanged throughout exercise in either condition. These results indicate that hypoxemia interferes with PRA-mediated aldosterone secretion. The variations in plasma ACTH levels during exercise in hypoxia do not appear responsible for this interference.
Key-Words
Plasma Renin Activity - Plasma Angiotensin Converting Enzyme Activity - Exercise - Hypoxia - Adrenocorticotrophic Hormone