Horm Metab Res 1988; 20(10): 620-623
DOI: 10.1055/s-2007-1010900
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Thyroid Hormones and Muscle Metabolism in Dogs

Barbara Kruk, Zofia Brzezinska, Hanna Kaciuba-Uscilko, Krystyna Nazar
  • Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
This work was supported by the Polish Academy of Sciences within the Project C.P.B.P. 06-02-III.2.1.
Further Information

Publication History

1987

1987

Publication Date:
14 March 2008 (online)

Summary

Muscle contents of ATP, ADP, AMP, creatine phosphate and creatine as well as glycogen, some glycolytic intermediates, pyruvate and lactate were compared in the intact, thyroidectomized and triiodothyronine (T3) treated dogs under resting conditions. After thyroidectomy muscle glycogen, glucose 1 -phosphate and glucose 6-phosphate contents were significantly elevated while in T3-treated animals these variables were decreased in comparison with control dogs. Muscle free glucose was not altered by thyroidectomy but T3 treatment significantly increased its content. Muscle lactate content was elevated both in hypo- and hyperthyroid animals. Muscle ATP and total adenine nucleotide contents were significantly increased in hyperthyroid dogs while no differences were found between the three groups in the muscle creatine phosphate content.

It is assumed that in T3-treated animals carbohydrate catabolism is enhanced in the resting skeletal muscle in spite of high tissue ATP content. Muscle metabolite alterations in hypothyroid dogs seem to reflect the hypometabolism accompanied by a diminished rate of glycogenolysis with inhibited rate of pyruvate oxidation or decreased rate of lactate removal from the cells.