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Horm Metab Res 1988; 20(11): 691-692
DOI: 10.1055/s-2007-1010918
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© Georg Thieme Verlag, Stuttgart · New York

Gossypol and Testicular Lipids of Adult Rats

D. S. Sheriff
  • Department of Biochemistry, Al Arab Medical University, Benghazi, Libya
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Publication History

1987

1987

Publication Date:
14 March 2008 (online)

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Summary

Testicular lipids act as source of energy, structural components of spermatozoa and precursors of androgen biosynthesis. Treatment with antispermatogeneic agents cause accumulation of testicular lipids. Gossypol, an effective antispermatogenic agent causes marked accumulation of testicular neutral lipids. It did not affect testicular phospholipids. Gossypol treatment did not bring about marked changes in the key enzymes like HMG Co A reductase, glucose-6-phosphate dehydrogenase malic enzyme and cytosolic isocitrate dehydrogenase involved in sterol biosynthesis. Thus, gossypol brings about marked accumulation of glycerides and esterified cholesterol in the testis due to its effect on spermatogenic elements of adult rats.

Key-Words

Gossypol - Testicular Lipids - HMG Co A Reductase - Glucose-6-Phosphate Dehydrogenase - Malic Enzyme - Isocitrate Dehydrogenase - Adult Rats