RSS-Feed abonnieren
DOI: 10.1055/s-2007-1010936
© Georg Thieme Verlag, Stuttgart · New York
Effects of Dietary NaCl Supplementation on Bone Synthesis of Hydroxyproline, Urinary Hydroxyproline Excretion and Bone 45Ca Uptake in the Rat
Publikationsverlauf
1987
1988
Publikationsdatum:
14. März 2008 (online)

Summary
High sodium chloride intakes are regarded as a risk factor for osteoporosis because they increase the obligatory urinary calcium loss and stimulate parathyroid activity. Sodium chloride loads induce osteopenia in the rat. The effect could be due to a decrease in bone formation or a rise in bone resorption. Two experiments were undertaken to study the effects of dietary NaCl supplementation on 3H-hydroxyproline synthesis and 45Ca uptake in femoral bone. Salt-treated rats excreted 1.7 times more total urinary hydroxyproline (P < 0.001) and 2.1 times more recently labelled 3H-hydroxyproline than controls (P < 0.02) but they did not accumulate less 3H-hydroxyproline or less 45Ca in their bones than controls. These results indicate that salt-mediated osteopenia is due to an increase in bone resorption, rather than to a decrease in bone formation.
Key-Words
Osteoporosis - Sodium Chloride - Bone Resorption - Bone Formation