Horm Metab Res 1988; 20(12): 743-745
DOI: 10.1055/s-2007-1010936
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Effects of Dietary NaCl Supplementation on Bone Synthesis of Hydroxyproline, Urinary Hydroxyproline Excretion and Bone 45Ca Uptake in the Rat

A. Goulding, E. Gold
  • Department of Medicine, University of Otago Medical School, Dunedin, New Zealand
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Publikationsverlauf

1987

1988

Publikationsdatum:
14. März 2008 (online)

Summary

High sodium chloride intakes are regarded as a risk factor for osteoporosis because they increase the obligatory urinary calcium loss and stimulate parathyroid activity. Sodium chloride loads induce osteopenia in the rat. The effect could be due to a decrease in bone formation or a rise in bone resorption. Two experiments were undertaken to study the effects of dietary NaCl supplementation on 3H-hydroxyproline synthesis and 45Ca uptake in femoral bone. Salt-treated rats excreted 1.7 times more total urinary hydroxyproline (P < 0.001) and 2.1 times more recently labelled 3H-hydroxyproline than controls (P < 0.02) but they did not accumulate less 3H-hydroxyproline or less 45Ca in their bones than controls. These results indicate that salt-mediated osteopenia is due to an increase in bone resorption, rather than to a decrease in bone formation.