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Horm Metab Res 1988; 20(12): 746-748
DOI: 10.1055/s-2007-1010937
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Insulin Resistance in Fibrocalculous (Tropical) Pancreatic Diabetes

V. Mohan, A. Ramachandran, G. Vijay Kumar, C. Snehalatha, M. Viswanathan
  • Diabetes Research Centre and M.V. Hospital for Diabetes, Madras, India
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Publication History

1987

1988

Publication Date:
14 March 2008 (online)

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Summary

Insulin resistance was assessed by Insulin Tolerance Test (ITT) in 12 patients with FCPD, 10 with NIDDM and 12 age and sex matched control subjects. The mean BMI of the FCPD was lower than the NIDDM and control groups (P < 0.001). There was no significant difference between the mean fasting plasma glucose or HbA1 between the FCPD and NIDDM patients. The mean fasting C-peptide of the FCPD group was significantly lower than the NIDDM and control groups (P < 0.001). The mean glucose disposal rate (KITT) was 5.57±2.28 in the control group, 2.15±2.00 in the FCPD and 1.77+0.91 in the NIDDM group (P < 0.001, control vs FCPD and NIDDM). The difference in KITT between FCPD and NIDDM groups was not significant statistically. The data suggests that patients with FCPD have evidence of insulin resistance and this is similar to that seen in NIDDM patients.

Key-Words

MRDM - FCPD - Tropical Diabetes - Chronic Pancreatitis - Insulin Resistance - Fibrocalculous Pancreatic Diabetes - Insulin Tolerance Test