Severe Hypoglycemia as a Short-Term Side-Effect of the Somatostatin Analog SMS 201-995 in Insulin-Dependent Diabetes Mellitus

I. Navascuès; J. Gil; C. Pascau; Diana Senen; M. Serrano-Rios

doi:10.1055/s-2007-1010938

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1988; 20(12): 749-750
DOI: 10.1055/s-2007-1010938

Clinical

Severe Hypoglycemia as a Short-Term Side-Effect of the Somatostatin Analog SMS 201-995 in Insulin-Dependent Diabetes Mellitus

I. Navascuès, J. Gil, C. Pascau, Diana Senen, M. Serrano-Rios

Servicio de Medicina Interna, Hospital Ramón y Cajal, Madrid, Spain

Abstract

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Summary

We report on a case of severe hypoglycemia observed after injection of the somatostatin analog SMS 201-995 in an insulin-dependent diabetic patient connected to an artificial pancreas (Biostator GCIIS). Hypoglycemia occurred in a sudden and unexpected way 23 min after the first SMS injection (50 ug). Details on patient's characteristics and on the peculiar clinical situation in which this complication appeared are given. Furthermore, the possible mechanism (s) responsible for the hypoglycemia are thoroughly discussed. Finally we express a call for caution when administering this drug in insulin-dependent diabetes mellitus.

Key-Words

Somatostatin Analog - Diabetes Mellitus - Hypoglycemia - Artificial Pancreas

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