Increase in Insulin Secretion Induced by Plasma from Mice Injected with Allogeneic Lymphocytes

J. B. García; M. C. Venturino; J. C. Cresto; O. H. Pivetta; J. C. Basabe

doi:10.1055/s-2007-1011803

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1987; 19(7): 290-294
DOI: 10.1055/s-2007-1011803

ORIGINALS

Increase in Insulin Secretion Induced by Plasma from Mice Injected with Allogeneic Lymphocytes

J. B. García¹ , M. C. Venturino¹ , J. C. Cresto¹ , O. H. Pivetta² , J. C. Basabe¹

¹Fundación Laboratorios de Investigaciones Pediátricas (FLIP), Hospital General de Niños Dr. P. de Elizalde, Buenos Aires, Argentina
²Instituto Nacional de Genética Médica, Buenos Aires, Argentina

Abstract

als PDF herunterladen

Summary

Plasma from BALB/c mice bled 90 minutes after allogeneic lymphocyte injection significantly rises glucose induced insulin secretion. This rise is observed in pancreas either from non-treated or from allogeneized mice. This rise is time and dose-dependent. An 1/40 dilution is enough to bring about a significant increase on insulin secretion. This effect is seen when mice are bled between 60 and 180 minutes after injection with a maximum effect at 90-120 minutes. Plasma from BALB/c mice injected with C57BL/6 J lymphocytes rises insulin secretion from BALB/c, C57BL/6 J, C3h and C57BL/KsJ mice pancreas. Plasma from streptozotocin diabetic BALB/c mice and from genetically diabetic C57BL/KsJ mdb-mdb mice injected with allogeneic lymphocytes stimulates glucose induced insulin secretion but to a lesser extent than plasma from normal non-diabetic mice does.

Key-Words

Insulin-Alloantigen-Diabetes

PDF (460 kb)