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DOI: 10.1055/s-2007-1011803
© Georg Thieme Verlag, Stuttgart · New York
Increase in Insulin Secretion Induced by Plasma from Mice Injected with Allogeneic Lymphocytes
Publikationsverlauf
1985
1986
Publikationsdatum:
14. März 2008 (online)

Summary
Plasma from BALB/c mice bled 90 minutes after allogeneic lymphocyte injection significantly rises glucose induced insulin secretion. This rise is observed in pancreas either from non-treated or from allogeneized mice. This rise is time and dose-dependent. An 1/40 dilution is enough to bring about a significant increase on insulin secretion. This effect is seen when mice are bled between 60 and 180 minutes after injection with a maximum effect at 90-120 minutes. Plasma from BALB/c mice injected with C57BL/6 J lymphocytes rises insulin secretion from BALB/c, C57BL/6 J, C3h and C57BL/KsJ mice pancreas. Plasma from streptozotocin diabetic BALB/c mice and from genetically diabetic C57BL/KsJ mdb-mdb mice injected with allogeneic lymphocytes stimulates glucose induced insulin secretion but to a lesser extent than plasma from normal non-diabetic mice does.
Key-Words
Insulin-Alloantigen-Diabetes