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Horm Metab Res 1987; 19(11): 534-537
DOI: 10.1055/s-2007-1011876
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© Georg Thieme Verlag, Stuttgart · New York

Variations of Susceptibility to Alloxan Induced Diabetes in the Rabbit

Z.-H. Zhao, B. Watschinger, C. D. Brown, Monica M. Beyer, E. A. Friedman
  • State University of New York Downstate Medical Center, Brooklyn, New York, U.S.A.
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Publication History

Publication Date:
14 March 2008 (online)

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Summary

The variations of susceptibility to alloxan induced Diabetes in a total of seventeen rabbits was described. Our study was designed to explore dosage schedules which might improve rabbit responsiveness to and survival after alloxan treatment.

A wide range of response to intravenously administered alloxan was observed. Permanent diabetes (blood glucose 350 mg/dl) was found in three rabbits after a single injection (60 mg/kg in one, 100 mg/kg in two). This effect has persisted for eight months. By contrast, two other rabbits injected with a single dose of alloxan (60 mg/kg) developed only transient hyperglycemia. Similarly, four other rabbits either did not respond or had an incomplete response after receiving a total dose of 120 mg/kg. These data suggest that there is extreme variability in individual rabbits susceptibility to the diabetogenic affects of alloxan.

Key-Words

Alloxan - Hyperglycemia - Diabetes Rabbit - Responsiveness - Variability