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Horm Metab Res 1987; 19(11): 542-544
DOI: 10.1055/s-2007-1011878
ORIGINALS
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© Georg Thieme Verlag, Stuttgart · New York

Chicken Glucagon: Sequence and Potency in Receptor Assay

J. Huang, J. Eng, R. S. Yalow
  • Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, NY, Mount Sinai School of Medicine, CUNY, New York, U.S.A.
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Publication History

Publication Date:
14 March 2008 (online)

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Summary

Glucagon is a 29 amino acid peptide that is generally highly conserved. Among mammalian glucagons the only one that has been shown to differ significantly is that of the guinea pig which differs from the others in 5 of the 9 COOH-terminus amino acids. The amino acid content and partial sequencing of chicken glucagon had been reported earlier. This report describes the purification and complete amino acid sequencing of chicken glucagon and demonstrates that it differs from the usual mammalian glucagons by the replacement of asparagine at position 28 with serine. Chicken glucagon is indistinguishable from porcine glucagon in the rat liver receptor assay system.

Key-Words

Chicken Glucagon - Mammalian Glucagon - Rat Liver - Receptor Assay