PDF herunterladen
Horm Metab Res 1987; 19(12): 604-605
DOI: 10.1055/s-2007-1011890
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

The Effect of Dopaminergic Blockade on Thyrotrophin Response to Thyrotrophin-Releasing Hormone and Somatostatin

A. Sánchez1 , E. Montoya2
  • 1Departamento de Investigación, Centro Ramón y Cajal de la Seguridad Social, Madrid, Spain
  • 2Departamento de Biología y Bioquímica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, Cádiz, Spain
Weitere Informationen

Publikationsverlauf

1986

1986

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

Using a large number of animals we have been able to demonstrate that somatostatin administration (20 μg/100 g bw) significantly reduces both basal serum thyrotrophin (TSH) levels and the response to thyrotrophin-releasing hormone (TRH) in the normal rat. Pretreatment with the dopaminergic antagonist domperidone resulted in increased TSH levels, increased response to TRH but no modification in the response to somatostatin.

Key-Words

TSH - TRH - Somatostatin - Domperidone