Requirement of a Compartmentalization for NADPH Oxidizing Site and Peroxidase-H2O2 in the Thyroid Iodinating System

N. Ait Hammou; A. Virion; D. Deme; J. Pommier

doi:10.1055/s-2007-1011891

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Horm Metab Res 1987; 19(12): 606-608
DOI: 10.1055/s-2007-1011891

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© Georg Thieme Verlag, Stuttgart · New York

Requirement of a Compartmentalization for NADPH Oxidizing Site and Peroxidase-H₂O₂ in the Thyroid Iodinating System

N. Ait Hammou, A. Virion, D. Deme, J. Pommier

INSERM - U.96, Unité de Recherche sur la Glande Thyroide et la Régulation Hormonale, Bicêtre, France

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Publication History

1986

1987

Publication Date:
14 March 2008 (online)

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Summary

In this study, it is shown that NADPH iodination occurs in a thyroid peroxidase-H₂O₂ system in presence of thyroglobulin, the normal iodination substrate. Previous data suggested that thyroid H₂O₂generation is a NADPH-dependent system. Present results support the concept of a Compartmentalization of the sites of NADPH oxidation and peroxidasic iodination.

Key-Words

Thyroid Peroxidase - NADPH - H₂O₂ Production