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Horm Metab Res 1986; 18(1): 53-55
DOI: 10.1055/s-2007-1012224
Clinical

© Georg Thieme Verlag, Stuttgart · New York

CCK-8 Antagonizes Apomorphine-Induced Growth Hormone Secretion in Normal Subjects

N. P. V. Nair, S. Lal, H. Eugenio, E. Lizondo, J. X. Thavundayil, P. L. Wood, P. Etienne, H. Guyda
  • Douglas Hospital Research Center, Montreal General Hospital and Protein and Polypeptide Laboratory, McGill University, Quebec, Canada
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Publication History

1983

1984

Publication Date:
14 March 2008 (online)

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Summary

Cholecystokinin octapeptide (CCK-8) (5 ug iv over 1.0 minutes) administered to normal men had no effect on basal growth hormone (GH) or prolactin secretion but significantly antagonized the GH response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg sc), 30 (P < 0.05) and 45 minutes (P < 0.01) after Apo injection (n=8). These results are compatible with an inhibitory effect of CCK-8 on certain DA mechanisms in the hypothalamic-pituitary axis. Whether CCK-8 affects DA function in other brain regions in man is unknown.

Key-Words

Apomorphine - Cholecystokinin Octapeptide - Growth Hormone - Prolactin