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Horm Metab Res 1986; 18(1): 67-68
DOI: 10.1055/s-2007-1012228
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© Georg Thieme Verlag, Stuttgart · New York

Effect of Low-Dose Dopamine Infusion on Insulin and Glucagon Release in Fasting Normal Man

J. M. C. Connell, G. H. Beastall1 , D. L. Davies2 , K. Buchanan3
  • MRC Blood Pressure Unit, Western Infirmary, Glasgow, Northern Ireland
  • 1The Royal Infirmary, Glasgow, Northern Ireland
  • 2The Gardiner Institute, Western Infirmary, Glasgow, Northern Ireland
  • 3The Royal Victoria Infirmary, Belfast, Northern Ireland
Further Information

Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

The effect of a low-dose infusion of dopamine on basal circulating concentrations of insulin, glucagon and glucose in six healthy male subjects is reported. Dopamine (0.1 μg/kg/min) or placebo was given intravenously for 60 minutes. During infusion of the catecholamine, circulating plasma dopamine was 3.46 ± 1 ng/ml. No change in circulating concentrations of insulin, glucagon and glucose were seen during infusion of dopamine when compared with placebo infusion. It is concluded that dopamine acting at a D2 receptor is unlikely to be of physiological importance in regulation of basal pancreatic islet cell function in man.

Key-Words

Insulin - Glucagon - Dopamine