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Horm Metab Res 1986; 18(2): 94-97
DOI: 10.1055/s-2007-1012240
ORIGINALS
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© Georg Thieme Verlag, Stuttgart · New York

Control of Rat Gastric Somatostatin Release by γ-Aminobutyric Acid (GABA)

H. Koop, R. Arnold
  • Abteilung Innere Medizin, Schwerpunkt Verdauungs- und Stoffwechselerkrankungen, Zentrum für Innere Medizin, Universität Marburg, Marburg, Germany
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Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

The influence of γ-aminobutyric acid (GABA) on gastric somatostatin and gastrin release was studied using an isolated perfused rat stomach preparation. GABA dose-dependently inhibited somatostatin release (maximal inhibition of 44% at 10-5 M GABA), whereas gastrin secretion was not affected. The GABA agonist muscimol led to a decrease in somatostatin release of similar magnitude. The GABA-induced changes were partially reversed by 10-5 M atropine. Gastrin secretion was not influenced by either protocol. It is concluded that GABA as a putative neurotransmitter in the enteric nervous system is inhibitory to rat gastric somatostatin release in vitro via cholinergic pathways.

Key-Words

γ-Aminobutyric Acid - Gastrin - Muscimol - Rat - Somatostatin - Stomach