Download PDF
Horm Metab Res 1986; 18(2): 107-109
DOI: 10.1055/s-2007-1012243
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Thyroid Hormones Stimulate the Release of Hepatic Lipase from Cultured Rat Hepatocytes

P. Hansson1 , E. Jensen2 , C.-H. Florén2 , P. Nilsson-Ehle1
  • 1Department of Clinical Chemistry, University of Lund, Lund, Sweden
  • 2Department of Internal Medicine, University of Lund, Lund, Sweden
Further Information

Publication History

1984

1984

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

We have investigated the effects of triiodothyronine (T3) and thyroxine (T4) on the heparin-stimulated release of hepatic lipase (HL) activity from cultured rat hepatocytes. Addition of T4 (1-10 nmol/l) to the culture medium for 24 h stimulated HL release from cells derived from normal and hypothyroid rats, whereas T3 (0.1-10 nmol/l) was active (at the highest concentration) only in hepatocytes from hypothyroid animals. The effects of T4 could largely be abolished by 5-iodo-2-thiouracil (0.1 mmol/l), an inhibitor of T4-5′-deiodinase. This indicates that the effects of T4 treatment are exerted by T3, formed by deiodination in the hepatocytes.

Key-Words

Hepatic Lipase - Hepatocytes - Propylthiouracil - Thyroxine - Triiodothyronine