Islet Cell Antibodies and Other Autoantibodies in South African Blacks and Indians with Insulin Dependent Diabetes Mellitus (IDDM)

M. A. K. Omar; G. F. Bottazzo; A. C. Asmal

doi:10.1055/s-2007-1012247

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1986; 18(2): 126-128
DOI: 10.1055/s-2007-1012247

Clinical

Islet Cell Antibodies and Other Autoantibodies in South African Blacks and Indians with Insulin Dependent Diabetes Mellitus (IDDM)

M. A. K. Omar¹ , G. F. Bottazzo² , A. C. Asmal³

¹Department of Medicine, University of Natal, Congella, South Africa,
²Department of Clinical Immunology, Middlesex Hospital, London, England
³Joslin Clinic and Harward University, Boston, Massachusetts, U.S.A.

Abstract

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Summary

The presence or absence of islet cell antibodies and other autoantibodies was determined in 47 African and 34 Indian patients with IDDM and 37 controls. Islet cell antibodies (ICA-IgG) were found in over a third of the patients and in only 2 controls. Complement fixing antibodies (ICA-Cf) were found in 10 % of patients, but in none of the controls. Persistence of ICA beyond 3 years was more frequent in Black compared to Indian patients. Parietal cell antibodies were found more often in patients (20 %) than controls (5 %) as were thyroid microsomal antibodies (11 % vs. 0 %). None of the patients or controls had adrenal antibodies.

Key-Words

Islet Cell Antibodies - Autoantibodies - IDDM - South African Blacks - Indians

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