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Horm Metab Res 1986; 18(4): 256-259
DOI: 10.1055/s-2007-1012288
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Lack of Effect of Thyrotropin-Releasing Hormone (TRH) on the Peripheral Plasma Levels of Pancreatic Glucagon in Man

A. Usman, S. Istanbullu
  • Division of Endocrinology, Department of Medicine, Hacettepe Medical School, Ankara, Turkey
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Publication History

1984

1985

Publication Date:
14 March 2008 (online)

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Summary

Based on the fact that human pancreas has thyrotropin-releasing hormone (TRH) immunoreactivity and bioactivity, we studied the effect of TRH on peripheral plasma levels of pancreatic glucagon (IRG) and insulin (IRI) in healthy subjects.

During the infusion of 400 μg TRH for 120 min basal plasma IRI and IRG levels did not change significantly. In addition, intravenous infusion of 400 μg TRH did not affect the increments in the plasma IRG levels and the decrements in the blood glucose during insulin hypoglycemia.

Key-Words

Thyrotropin-Releasing Hormone - Insulin - Glucagon - Pancreas