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Horm Metab Res 1986; 18(7): 490-492
DOI: 10.1055/s-2007-1012353
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Effect of Parathyroid Hormone on Plasma Renin Activity in Humans

P. D. Broulik, K. Horký, V. Pacovský
  • 3rd Department of Internal Medicine and Laboratory of Endocrinology and Metabolism, Charles University, Faculty of Medicine, Prague, Czechoslovakia
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Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

The effect of PTH infusion on PRA was evaluated in 22 normotensive subjects. Intravenous infusion of PTH produced an increase in PRA in studied subjects. This increase in PRA was dose dependent from 1.505±0.226 to 2.500±0.346 nmol/l/hour after administration of 100 units of PTH and from 1.648±0.189 to 4.294±0.614 nmol/l/hour after 200 units of PTH and was markedly decreased by a beta blocking drug from 1.660±0.259 to 2.498±0.485 nmol/l/hour. These responses were observed without any significant changes in plasma calcium and blood pressure. From our results we can conclude that PTH increases PRA in normotensive controls. This effect is partly blocked by beta adrenergic blockers.

Key-Words

Parathormone Infusion - Plasma Renin Activity - Beta-Blocker Effect - Plasma Calcium - Blood Pressure