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Horm Metab Res 1986; 18(9): 607-610
DOI: 10.1055/s-2007-1012386
Clinical

© Georg Thieme Verlag, Stuttgart · New York

A Study of the Hypolipidemic Effect of Estrogen in Type III Hyperlipoproteinemia

P. M. J. Stuyt, P. N. M. Demacker, A. van 't Laar
  • Division of General Internal Medicine, Department of Medicine, University of Nijmegen, Nijmegen, The Netherlands
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Publication History

1985

1985

Publication Date:
23 April 2008 (online)

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Summary

Ethinylestradiol (1 μg/kg/day during 15 days) resulted in a gradual decrease of serum cholesterol, serum triglycerides (TG), very low density lipoprotein (VLDL) cholesterol and VLDL-TG in 2 postmenopausal women and 2 men with type III hyperlipoproteinemia (HLP). The turnover rate of VLDL-TG did not change. These findings contrast with previous observations in normal subjects and patients with type IV HLP. Thus, the catabolism of VLDL and VLDL-remnants increased during treatment with estrogen in type III HLP, probably by direct degradation of VLDL-remnants because in the initial days of treatment no increase of LDL-cholesterol was observed.

Key-Words

Estrogen - Hyperlipoproteinemia - Lipoproteins - Triglyceride Turnover