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DOI: 10.1055/s-2007-1012404
© Georg Thieme Verlag, Stuttgart · New York
Increased Release of Gastrin in Hyperthyroid Rats In Vitro
Publication History
1985
1985
Publication Date:
14 March 2008 (online)
Summary
The extrinsically denervated and vascularly perfused stomach of the hyperthyroid rat exhibits an increased basal gastrin release and an exaggerated response to stimulation with the b-agonist isoproterenol. The b-blocker propranolol does not inhibit the increased basal release of gastrin, but completely blocks the effect of isoproterenol. Vagal stimulation is not different between hyperthyroid and euthyroid rats.
We conclude, that there are two mechanisms which are responsible for the increased release of gastrin in hyperthyroidism: firstly a direct effect of thyroid hormones on gastrin cells, and secondly an increase in sensitivity of gastrin cells towards b-adrenergic stimulation.
Key-Words
Hyperthyroidism - Isolated Perfused Stomach - Gastrin Release