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Horm Metab Res 1986; 18(11): 739-742
DOI: 10.1055/s-2007-1012423
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Kaluresis Independent K-Homeostasis: Glucagon and B Receptor Blockade in Pancreatectomized Dogs

N. Hiatt, L. W. Chapman, M. B. Davidson, H. Mack
  • Department of Surgery, Medicine and the Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, U.S.A.
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Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

Seventy minutes post pancreatectomy, in dogs that are K loaded - made abruptly hyperkalemic and “life threatened” - by infusion with 2 mEgKC1/kg-/hr until prelethal ECG changes of hyperkalemic cardiotoxicity appear, a kaluresis independent K homeostatic mechanism transfers about 2/3 of administered K to intracellular fluid. Treatment of K loaded pancreatectom-ized dogs with glucagon or a B receptor blockading dosage of propranolol does not alter the proportion transferred, but treatment with glucagon and propranolol reduces it. It appears that in pancx dogs there is a reciprocal relation between insulin and B receptor mediated K transfer and that glucagon is involved in activity of the kaluresis Independent K homeostatic mechanism.

Key-Words

Pancreatectomy - Glucagon - Hyperkalemia - Propranolol - K homeostasis - B receptor blockade