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Horm Metab Res 1986; 18(11): 743-745
DOI: 10.1055/s-2007-1012424
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Effect of Adrenalectomy on the Pancreas of db/db Mice

G. S. Spear1 , K. Ohshima2 , G. A. Bray2 , M. V. Caple1
  • 1Department of Pathology, University of California Irvine, Irvine, California, U.S.A.
  • 2Department of Medicine, University of Southern California, Los Angeles, California, U.S.A.
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Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

Adrenalectomy has been performed in the diabetic mouse and the islet immunohistochemistry studied. Adrenalectomy restored blood glucose to normal. Mean islet size of diabetic animals was larger than that of either adrenalectomized diabetic animals or of lean controls. Adrenalectomy restored the immunohistochemical appearance of the islets to normal when examinded with anti-insulin, anti-glucagon and anti-somatostatin antisera.

Key-Words

Adrenalectomy - Islets - db/db Mice - ob/ob Mice - Immunohistochemistry - Pancreas - Somatostatin - Insulin - Glucagon