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Horm Metab Res 1986; 18(11): 757-760
DOI: 10.1055/s-2007-1012428
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© Georg Thieme Verlag, Stuttgart · New York

Mouse Soleus Muscle Na-K Pump Activity: Direct Correlation with In Vitro and In Vivo Oxygen Consumption

S. Saddlier, M. De Luise
  • University of Melbourne Department of Medicine, Repatriation General Hospital, Heidelberg, Victoria, Australia
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Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

To evaluate the contribution of active sodium-potassium transport to energy utilization, measurements of sodium-potassium pump activity in isolated soleus muscles of normal mice were carried out and related to measurements of oxygen consumption by the tissue.

A highly significant positive correlation (r = 0.89, p < 0.001) was found between these two parameters. In addition, both the in vitro oxygen consumption and Na-K pump activity of the muscles were found to correlate with whole body oxygen utilization by the experimental animals.

The results support a role for the sodium-potassium pump in the determination of energy turnover.

Key-Words

Na-K Pump - Metabolic Rate - Skeletal Muscle - Oxygen Consumption