Hormone and Metabolic Research, Inhaltsverzeichnis Horm Metab Res 1986; 18(11): 768-770DOI: 10.1055/s-2007-1012431 Clinical © Georg Thieme Verlag, Stuttgart · New York Glucocorticoid-Related Impairment in the Metabolism of Low Density Lipoprotein by Human Fibroblasts J. D. Bagdade, J. J. Albers, P. V. Subbaiah Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, and the Northwest Lipid Research Clinic, Seattle, Washington, U.S.A. Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Summary The metabolism of radiolabelled 125I-low density lipoprotein (LDL) was studied in cultured human dermal fibroblasts to investigate potential mechanisms contributing to the accelerated development of cardiovascular disease in patients treated chronically with corticosteroids. Fibroblasts exposed for 48 hours to pooled lipoprotein-poor (d > 1.25gm/ml) serum from glucocorticoid-treated patients showed an increased capacity to bind LDL (p <.001) compared to cells incubated under identical conditions with pooled serum from controls. In addition, a significantly (p < .001) reduced amount of soluble radioactive material appeared in the media indicating that exposure of fibroblasts to corticosteroid serum also impaired their capacity to degrade LDL. If this tendency of cultured cells to accumulate cholesterol-rich lipoprotein when exposed to constituents of serum from these patients is present in patients receiving long-term treatment with glucocorticoids, it might influence arterial lipid accumulation and accelerate their developing cardiovascular disease. Key-Words Glucocorticoids - Fibroblasts - Low Density Lipoprotein - Metabolism - Atherogenesis PDF (282 kb)
