Ano-rectal Lesions in Patients Taking Suppositories Containing Non-steroidal Anti-inflammatory Drugs (NSAID)

G. Gizzi; V. Villani; G. Brandi; G. M. Paganelli; G. Di Febo; G. Biasco

doi:10.1055/s-2007-1012822

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Endoscopy 1990; 22(3): 146-148
DOI: 10.1055/s-2007-1012822

Ano-rectal Lesions in Patients Taking Suppositories Containing Non-steroidal Anti-inflammatory Drugs (NSAID)

G. Gizzi, V. Villani, G. Brandi, G. M. Paganelli, G. Di Febo, G. Biasco

Istituto di Clinica Medica e Gastroenterologia, Università di Bologna, Bologna, Italy

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Publikationsdatum:
17. März 2008 (online)

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Summary

We report on 3 cases in which ano-rectal lesions were associated with chronic administration of suppositories containing non-steroidal anti-inflammatory drugs (NSAID). Lesions were characterized by erosions or ulcer in the rectum and by stenosis of the anal verge. Erosions or ulcers were observed in patients taking the drugs for a relatively short time. The lesions remitted after suspension of the treatment. The cases observed indicate that suppositories containing NSAID could induce ano-rectal lesions similar to those observed after the use of suppositories containing ergotamine.

Key words:

Proctitis - Non-steroidal anti-inflammatory drugs (NSAID) - Suppositories