Summary
The inhibitory action on somatostatin (ST) on the spontaneous and stimulated (pentagastrin
18 μg/kg/h i.v. and histamine 5 mg/kg/h i.v.) gastric acid secretion and its modification
after pretreatment with an inhibitor of endogenous prostaglandins biosynthesis (indomethacin
5 mg/kg i.v.) has been studied in the anaesthetized rat.
ST 30 μg/kg/h i.v. inhibits basal and stimulated gastric acid secretion. In the presence
of indomethacin the inhibition elicited by ST on basal and pentagastrin induced gastric
acid secretion was partially attenuated, whereas in the histamine group the inhibitory
action was totally abolished. The antagonism elicited by indomethacin was not surmounted
by increasing (x3.3) the dose of ST.
These findings suggest that endogenous prostalgandins may be involved in the mechanism
by which ST exerts its antisecretory effect in this model.
Key-Words:
Acid Secretion
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Histamine
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Indomethacin
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Pentagastrin
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Somatostatin
