PDF herunterladen
Horm Metab Res 1985; 17(6): 289-292
DOI: 10.1055/s-2007-1013521
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Effect of Resection of Small Intestine on the Interaction of Vasoactive Intestinal Peptide with Rat Colonic Epithelial Cells

M. D. Fernández-Moreno, J. L. Díaz-Juárez, E. Arilla, J. C. Prieto
  • Departamento de Bioquimica, Facultad de Medicina, Universided de Alcalá de Henares-Madrid, Spain
Weitere Informationen

Publikationsverlauf

1983

1984

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

Vasoactive intestinal peptide (VIP) receptors and VIP-dependent cyclic AMP production were studied in rat colonic epithelial cells 3 days after a 60% resection of the small intestine. Basal cyclic AMP levels were similar in both control and resected animals. The potency, but not the efficiency, of the peptide on the stimulation of cyclic AMP production was diminished in cells from resected rats. Accordingly, the affinity of VIP receptors, but not the binding capacity, decreased as a consequence of the loss of a part of the small intestinal mucosa. These observations are consistent with the known inhibitory role of cyclic AMP on cell proliferation in colonic epithelium and other tissues and suggest a participation of VIP acting through the cyclic nucleotide in the compensatory hyperproliferative response of the colon following massive resection of the small intestine.

Key-Words:

Vasoactive Intestinal Peptide - Proliferation - Receptors - Cyclic AMP - Colonic Epithelial Cells