PDF herunterladen
Horm Metab Res 1985; 17(6): 311-312
DOI: 10.1055/s-2007-1013527
Clinical

© Georg Thieme Verlag, Stuttgart · New York

The Effect of Calcium Supplements on Plasma Alkaline Phosphatase and Urinary Hydroxyproline in Postmenopausal Women

M. Horowitz1 , A. G. Need2 , J. C. Philcox2 , B. E. C. Nordin1
  • 1Department of Endocrinology, Royal Adelaide Hospital, Adelaide, South Australia
  • 2Division of Clinical Chemistry, Institute of Medical and Veterinary Science, Adelaide, South Australia
Weitere Informationen

Publikationsverlauf

1983

1984

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

Although calcium supplements are widely used in the treatment of osteoporosis, their beneficial effect is not conclusively established. We now report some effects of a calcium supplement (1 g/day) given for 6 to 12 weeks to 15 postmenopausal osteoporotic women. The mean fasting urinary hydroxyproline/creatinine ratio decreased from 0.021 ± 0.002 to 0.015 ± 0.001 (P < 0.0025), indicating a significant reduction in bone resorption. The mean plasma alkaline phosphatase fell from 123 ± 5 U/l to 104 ± 3.1 U/l (P < 0.01), probably representing some secondary reduction in bone formation following the inhibition of bone resorption. These results support the concept that calcium supplementation is useful in the treatment of post-menopausal osteoporosis.

Key-Words:

Osteoporosis - Calcium Supplements - Hydroxyproline