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DOI: 10.1055/s-2007-1014808
© Georg Thieme Verlag, Stuttgart · New York
Effects of Anti-Thyrotropin-Releasing Hormone Anti-Serum Treatment during the Neonatal Period on the Development of Rat Thyroid Function
Publication History
1983
1983
Publication Date:
14 March 2008 (online)
![](https://www.thieme-connect.de/media/hmr/198408/lookinside/thumbnails/10.1055-s-2007-1014808-1.jpg)
Summary
Effects of anti-thyrotropin-releasing hormone (TRH) antiserum treatment during the neonatal period on the development of rat thyroid function were studied. On postnatal days 2 and 4, rats were administered anti-TRH anti-serum ip, and they were serially decapitated at the 4th, 8th and 12th week after birth. TRH, thyrotropin (TSH), thyroxine (T4) and 3,3′,5-triiodothyronine (T3) were measured by radioimmunoassay.
Immunoreactive TRH (ir-TRH) in the hypothalamus did not change significantly after anti-TRH anti-serum treatment, and plasma ir-TRH tended to decrease. The plasma ir-TRH and TSH responses to cold were significantly inhibited. The plasma TSH response to TRH was also significantly inhibited. The plasma basal TSH levels were significantly lower than incontrols.The plasma T4 and T3 levels were found to be lower than those in the controls.
Findings suggested that treatment with anti-TRH antiserum during the neonatal period disturbed the development of rat thyroid function, inhibiting TRH release and altering thyrotroph sensitivity to TRH.
Key-Words:
Thyrotropin-Releasing Hormone - Thyrotropin - Anti-TRH Anti-serum - Development of Thyroid Function