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DOI: 10.1055/s-2007-1014809
© Georg Thieme Verlag, Stuttgart · New York
Regulation of Phosphatidylcholine Biosynthesis by the Methylation Pathway in Rat Pituitary Gland
Publication History
1983
1983
Publication Date:
14 March 2008 (online)
![](https://www.thieme-connect.de/media/hmr/198408/lookinside/thumbnails/10.1055-s-2007-1014809-1.jpg)
Summary
Rat pituitary extracts catalyze methylation of phosphatidylethanolamine to phosphatidylcholine using S-adenosyl-L-methionine as the methyl donor. In vitro incubation of hemipituitaries with 1 mM 2-methylaminoethanol led to a dose dependent de-crease in phosphatidylethanolamine methyltransferase activity as well as the incorporation of the radioactivity from [3H-methyl]-L-methionine into phosphatidyl-choline. The inhibitory effect of 2-methylaminoethanol was selective for phosphoiipids methylation since protein carboxymethyltransferase and catechol-o-methyltransferase activities were not affected.
Key-Words:
Phosphatidylcholine - Phospholipid methylation - Choline - Pituitary - 2-Methylaminoethanol