Amelioration of Streptozotocin-Induced Diabetes in the Rat by Exercise-Training: Role of Muscle Glycogenolytic and Glycolytic Enzyme Activity

Summary

Streptozotocin-induced insulin deficient rats allowed to run at will had significantly (P < 0.001) lower mean (± SEM) plasma glucose levels (12.1 ± 0.9 vs 22.6 ± 1.7 mM/l) than did equally insulin deficient sedentary rats. Mutscle glycogen phosphorylase and synthase activities were similar in exercise-trained and sedentary diabetic rats, and were unchanged fromcontrol values. In contrast, muscle phosphofructokinase activity was reduced (P < 0.001) in sedentary rates with insulin deficiency, and the defect was significantly reversed ( P ± 0.01) when such rats were allowed to run spontaneously. These results are consistent with the view that the ability of exercise-training to attenuate the magnitude of hyperglycemiain streptozotocin-induced insulin deficiency is associated with an effect on a key regulatory enzyme in the glycolytic pathway

Key-Words:

Exercise Training - Insulin-Deficient Diabets - Muscle Enzymes - Muscle Phosphofructokinase Activity - Muscle Glycogen Synthase Activity - Muscle Phosphorylase Activity