Summary
To examine the relative importance of the stomach for the enteroinsular axis, the
portal insulin secretion was measured in the rats with gastrectomy, after intraduodenal
(I.D.) infusion of 0.5 g/kg glucose and after intravenous (I.V.) infusion of the same
deal of glucose, respectively.
Portal plasma gastrin was decreased from 100 pg/ml to 5 pg/ml by gastrectomy. Blood
sugar level after I.D. and I.V. infusion of glucose in the rats with gastrectomy was
similar to controls. Insulin release to I.D. infusion of glucose was slightly lower
at 30 minutes in the gastrectomized rats compared with controls, while insulin secretion
to I.V. infusion of glucose was similar to controls.
These results suggest that endogenous gastrin has no insulinotropic effect and that
the stomach has no direct effect on glucose-induced insulin release.
Key-Words:
Enteroinsular Axis
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Gastrectomy
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Gastrin
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Insulin Secretion
