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DOI: 10.1055/s-2007-1014913
© Georg Thieme Verlag, Stuttgart · New York
TRH-Induced Growth Hormone Release in Insulin-Dependent Diabetes Mellitus
Publikationsverlauf
1983
1983
Publikationsdatum:
14. März 2008 (online)
Summary
Growth hormone (GH) response was studied in 8 insulin-dependent and 7 non-insulin-dependent diabetics after stimulation with L-Dopa (500 mg orally) and TRH (0.2 mg iv.). L-Dopa induced a clear GH response in insulin-dependent diabetes (IDDM) and in the control group while in non-insulin-dependent diabetes (NIDDM) peak GH levels were lower (P < 0.05) and 4 of 7 subjects failed to respond to L-Dopa stimulation. TRH had no effect on GH levels in NIDDM and in the controls. Insulin-dependent diabetics responded to TRH stimulation and GH levels at 20 and 30 min were significantly higher as compared with NIDDM and the control group. The degree of hyperglycemia seemed not to influence GH response. The highest GH levels were noted in two patients with proliferative retinopathy. It is suggested that TRH-induced GH release may be a characteristic feature in some patients with IDDM.
Key-Words:
Diabetes Mellitus - Growth Hormone - TRH - L-Dopa