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DOI: 10.1055/s-2007-1014926
Insulin Binding to Erythrocytes in Children with Type I Diabetes Mellitus before, and after Insulin Treatment
Publikationsverlauf
1983
1984
Publikationsdatum:
14. März 2008 (online)
Summary
125I-insulin binding to erythrocytes was studied in 24 children with type I diabetes mellitus before institution of insulin therapy, and in 10 normals. Mean specific 125I-insulin binding in the diabetics was significantly lower than in the controls (10.2 ± 0.4% (SEM), as against 11.6 ± 0.5%, P < 0.05). In 8 diabetics the study was repeated after 3-6 weeks of therapy, at which time the insulin binding had increased to normal (12.1%, range 10.7-13.6). No Correlation was found between insulin binding and blood glucose, plasma insulin or plasma β-hydroxybutyrate. We conclude that insulin binding to the receptors is altered in the early phase of type I diabets
Key-Words:
Insulin Receptor - Erythrocytes - Type I Diabetes