Exercise-Induced Changes of Factor VIII Complex in Healthy Subjects and in Type-I Diabetics: Relation between Growth Hormone and Von Willebrand Factor Increments

Mariella Trovati; G. Tamponi; S. Marra; R. Lorenzati; Piercarla Schinco; M. Bazzan; Sara Vitali; F. Cavalot; G. Pagano; G. Lenti

doi:10.1055/s-2007-1018708

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1983; 15(7): 316-320
DOI: 10.1055/s-2007-1018708

Exercise-Induced Changes of Factor VIII Complex in Healthy Subjects and in Type-I Diabetics: Relation between Growth Hormone and Von Willebrand Factor Increments

Mariella Trovati¹ , G. Tamponi¹ , S. Marra² , R. Lorenzati¹ , Piercarla Schinco¹ , M. Bazzan¹ , Sara Vitali¹ , F. Cavalot¹ , G. Pagano¹ , G. Lenti¹

¹Istituto di Medicina Interna dell'Universita' di Torino, Torino, Italy
²Divisione di Cardiologia dell'Ospedale San Giovanni Battista di Torino, Torino, Italy

Abstract

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Summary

This work aims to study the exercise-induced changes of Factor VIII Complex both in healthy subjects and in type I diabetics without vascular complications, and to investigate the possible relations between growth hormone and Von Willebrand's Factor response to exercise.

Results show that maximal exercise performed by cycle ergometer causes a significant increment of the procoagulant subunit (VIII:C) and of Von Willebrand Factor (VIII:RiCoF) both in healthy controls and in type I diabetics, whereas a slight increment of Factor VIII-Related antigen (VIIIR:Ag) is observed only in diabetics. The shape of the mean GH response to exercise parallels the one of Von Willebrand's Factor: however, the presence of VIII:RiCoF increments also in GH non-responders supports the conclusion that growth hormone is not the only factor involved in the regulation of Von Willebrand's Factor exercise-induced increase.

Key-Words:

Maximal Exercise - Type I Diabetes Mellitus - Factor VIII Complex - Von Willebrand's Factor - Growth Hormone

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