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Horm Metab Res 1982; 14(2): 65-68
DOI: 10.1055/s-2007-1018925
© Georg Thieme Verlag, Stuttgart · New York

Glucagon Receptors: Are They Present on Human Blood Cells?

V. W. M. van Hinsbergh, W. J. Nooijen, H. J. M. Kempen
  • Gaubius Institute TNO, Leiden, The Netherlands
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Publication History

1980

1981

Publication Date:
22 April 2008 (online)

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Summary

Binding of glucagon to and its degradation by human mononuclear leucocytes and erythrocytes was investigated. Labeled glucagon binds to these cells, but can only be displaced by unlabeled glucagon at pharmacologically high concentrations. It is concluded that glucagon binding to human blood cells does not represent receptors of physiological importance and is of no value for the determination of glucagon sensitivity in man.

Key-Words:

Glucagon Binding - Human Mononuclear Leucocytes - Erythrocytes