Effects of 2-Deoxy-D-Glucose on Plasma and Adrenal Concentrations of Corticosterone and Aldosterone in Standard Diet Fed and Potassium Loaded Rats

Summary

The concentrations of corticosterone, aldosterone and electrolytes (Na⁺ and K⁺) were measured in the plasma and adrenal glands, following 2-deoxy-D-glucose (2-DG) treatment (2 injections of 50 mg/ml/100 g body weight) in standard diet fed and potassium loaded rats.

In both regimes, 2-DG increased the concentrations of corticosterone mainly in the plasma (+144.8 % and 229.5 %) and to a lesser extent, in the adrenal glands (+50.9 % and 62.5 %).

Conversely, 2-DG treatment was followed by a steep decline in plasma concentrations of aldosterone both in standard diet fed rats (-65.2 %) and in potassium loaded rats (-83.9 %), in spite of a marked increase in plasma (+233.3 %) and in adrenal (+54.9 %) levels of aldosterone after potassium loading; adrenal aldosterone content was essentially the same.

Plasma and adrenal electrolytes concentrations and hematocrit varied very little after 2-DG treatment.

Key-Words:

2-Deoxy-D-Glucose - Corticosterone - Aldosterone - Rat