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Horm Metab Res 1982; 14(5): 248-251
DOI: 10.1055/s-2007-1018984
© Georg Thieme Verlag, Stuttgart · New York

Modulation by Insulin and Glucagon of the Rate of [3H] H2O Incorporation into Glycerolipids by Isolated Rat Hepatocytes

A. C. Beynen1 , A. J. Van der Molen, M. J. H. Geelen
  • Laboratory of Veterinary Biochemistry, State University of Utrecht, Utrecht, The Netherlands
  • 1Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands
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Publikationsverlauf

1981

1981

Publikationsdatum:
23. April 2008 (online)

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Summary

Isolated rat hepatocytes in suspension were used to study the effects of insulin and glucagon on [3H]H2O incorporation into glycerolipids. Insulin was found to stimulate the incorporation of 3H into the acyl groups of triacylglycerols, phosphatidylcholines and phosphatidylethanolamines. The incorporation of 3H from [3H]H2O into the glycerol backbone of triacylglycerols is also enhanced by insulin. Glucagon has an inhibitory effect on all these parameters.

Key-Words:

Insulin - Glucagon - Hepatocytes - Triacylglycerol Synthesis - Phosphatidylcholine Synthesis - Phosphatidylethanolamine Synthesis