Effects of Adrenalectomy on the Hypothalamic-Pituitary-Thyroid Axis in Rats

T. Mitsuma; T. Nogimori

doi:10.1055/s-2007-1019004

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Horm Metab Res 1982; 14(6): 317-319
DOI: 10.1055/s-2007-1019004

Effects of Adrenalectomy on the Hypothalamic-Pituitary-Thyroid Axis in Rats

T. Mitsuma, T. Nogimori

Fourth Department of Internal Medicine Aichi Medical University, Nagakute, Aichi, Japan

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Publication History

1981

1981

Publication Date:
14 March 2008 (online)

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Summary

TRH and TSH levels in plasma were increased and TSH responsiveness to TRH was enhanced by adrenalectomy. T₄ and T₃ levels in plasma were increased after adrenalectomy, but rT₃ levels in plasma did not change. Findings suggested that adrenalectomy might affect the multiple sites of the hypothalamic-pituitary-thyroid axis in rats, causing changes in secretion or degradation of TRH, TSH and thyroid hormones.

Key-Words:

Adrenalectomy - Thyrotropin Releasing Hormone - Thyrotropin - Thyroxine - Triiodothyronine