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Horm Metab Res 1982; 14(9): 445-448
DOI: 10.1055/s-2007-1019044
© Georg Thieme Verlag, Stuttgart · New York

Host Defense in Diabetes Mellitus: Defective Membrane Synthesis during Phagocytosis

P. V. Subbaiah, J. D. Bagdade
  • University of Washington School of Medicine, Providence Medical Center, Seattle, Washington, U.S.A.
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Publication History

1981

1981

Publication Date:
14 March 2008 (online)

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Summary

During phagocytosis, polymorphonuclear leukocytes from poorly controlled diabetic patients convert lysolecithin to lecithin at a lower rate than cells from control subjects. This defect is partially reversed by treatment with insulin. By reducing the availability of structural lipid for formation of the phagocytic vacuole which normally takes place during phagocytosis, this impairment may compromise cellular hostdefense mechanisms in some diabetic patients.

Key-Words:

Phagocytosis - Diabetic Leukocytes - Lecithin Synthesis - Lysolecithin Acylation - Membrane Synthesis