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Horm Metab Res 1981; 13(4): 199-202
DOI: 10.1055/s-2007-1019220
© Georg Thieme Verlag, Stuttgart · New York

Glutamine Synthetase Activity in the Organs of Fed and 24-Hours Fasted Rats

Ll. Arola, A. Palou, X. Remesar, Marià Alemany
  • Fisiologia General, Facultat de Biologia, Universitat de Barcelona, Barcelona; Bioquímica, Facultat de Ciències, Universitat de Ciutat de Mallorca, Ciutat de Mallorca, Balears, Spain and Bioquimica, Facultat de Quimíca, Universitat de Barcelona, Dependències de Tarragona, Tarragona, Spain
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Publication History

1979

1980

Publication Date:
23 April 2008 (online)

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Summary

Glutamine synthetase activity in several rat tissues has been measured. Liver contains the highest specific activity followed by stomach, brain, kidneys, intestine, skin, adipose tissue and striated muscle - that had the lowest specific activity both with regard to tissue, protein and DNA weight. Per unit of animal weight, liver and muscle contain similar activities. 24 Hours of fasting induced a significant decrease in liver, stomach, intestine and skin glutamine synthetase, compensated by an increase in muscle activity. During fasting, the splanchnic glutamine synthetase activity is lowered and that of peripheral tissues is increased, thus favoring a net glutamine flux from peripheral to splanchnic organs.

Key-Words:

Glutamine Synthetase - Fasting