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DOI: 10.1055/s-2007-1019227
Effects of Glucocorticoids on Hormone-Stimulated Lipolysis and Calcium Uptake in the Adipose Cells
Publication History
1980
1980
Publication Date:
23 April 2008 (online)
Summary
Hormone-induced lipolysis and calcium accumulation were concomitantly reduced in the adipose tissue from adrenalectomized rats. In contrast, both epinephrine-activated lipolysis and calcium accumulation were potentiated when the adipocytes were preincubated with 33 ng/ml of dexamethasone for 3 hrs.
These potentiating effects of dexamethasone on epinephrine-stimulated lipolysis were completely inhibited when the adipocytes were preincubated with the steroid and verapamil which inhibited hormone-induced calcium influx into the adipocytes. These findings suggest that the potentiating effect of glucocorticoid on hormone-stimulated lipolysis depends upon its accerelating action on hormone-induced calcium influx into the adipocytes.
Key-Words:
Lipolysis - Adipocytes - Calcium Accumulation - Glucocorticoid - Adrenalectomy