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Horm Metab Res 1981; 13(7): 394-395
DOI: 10.1055/s-2007-1019279
© Georg Thieme Verlag, Stuttgart · New York

Partition of Thyroid Hormone among Erythrocyte Cytosol, Erythrocyte Membrane and Human Plasma Binding Sites

K. Yoshida, P. J. Davis
  • Division of Endocrinology, Department of Medicine, State University of New York at Buffalo School of Medicine and the Erie County Medical Center, New York, U.S.A.
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1980

1980

Publikationsdatum:
14. März 2008 (online)

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Summary

The partition of thyroid hormone among binding sites on plasma proteins, erythrocyte (RBC) membranes and cytoplasmic proteins has been examined in the context of recent direct estimates of intracellular RBC thyroid hormone content. Isotopic T3 and T4 uptakes by washed RBCs are identical (> 80 % of tracer at 4 hr), but RBC binding when RBCs are suspended in plasma favors T3 (10 % uptake vs. 2.5 % for T4). The RBC cytosol : plasma T3 ratio is 1 : 21.

Key-Words:

Thyroxine - Triiodothyronine - Plasma Proteins - Cytoplasm