Serial Measurement of Arterial and Internal Jugular Venous Creatine Kinase Isoenzyme BB (CK-BB) after Deep Hypothermie Total Circulatory Arrest in Pediatric Cardiac Surgery*

R. Ekroth; R. F. Rossi; V. Tsang; A. P. Jackson; R. J. Thompson; M. Scallan; C. Lincoln

doi:10.1055/s-2007-1020416

The Thoracic and Cardiovascular Surgeon, Inhaltsverzeichnis

Thorac Cardiovasc Surg 1986; 34(4): 223-225
DOI: 10.1055/s-2007-1020416

Serial Measurement of Arterial and Internal Jugular Venous Creatine Kinase Isoenzyme BB (CK-BB) after Deep Hypothermie Total Circulatory Arrest in Pediatric Cardiac Surgery*

R. Ekroth³ , R. F. Rossi¹ , V. Tsang¹ , A. P. Jackson² , R. J. Thompson² , M. Scallan¹ , C. Lincoln¹

¹Brompton Hospital, London, UK
²Department of Clinical Biochemistry, University of Cambridge, UK
³Department of Thoracic and Cardiovascular Surgery, University Hospital, Uppsala, Sweden

* This study was supported by grant B86-17X-07177-02A from the Swedish Medical Research Council and by grant from Gambro AB, Lund, Sweden

Abstract

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Summary

Profound hypothermia and circulatory arrest in infants and children undergoing cardiac surgery were followed by abnormally high plasma levels of creatine kinase isoenzyme BB (CK-BB). Differences in the levels of enzymes in the femoral arterial and jugular venous blood indicated that the origin of the additional enzyme was the brain. The extent of the rise in enzyme levels was related to the duration of circutatory arrest. These data suggest that measurements of the CK-BB enzyme in plasma provide quantitative Information about cerebral damage during cardiac surgery.

Key words

Brain damage - Ischemia - Surgery of congenital heart defects

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