Effects of Aerobic Exercise Training on Lymphocyte Subpopulations

A. LaPerriere; M. H. Antoni; G. Ironson; A. Perry; P. McCabe; N. Klimas; L. Helder; N. Schneiderman; M. A. Fletcher

doi:10.1055/s-2007-1021127

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 1994; 15: S127-S130
DOI: 10.1055/s-2007-1021127

Effects of Aerobic Exercise Training on Lymphocyte Subpopulations

A. LaPerriere¹ ^, ² ^, ³ ^, ⁵ , M. H. Antoni² ^, ³ , G. Ironson¹ ^, ² ^, ³ , A. Perry⁵ , P. McCabe³ , N. Klimas² ^, ⁴ , L. Helder² ^, ³ , N. Schneiderman¹ ^, ² ^, ³ ^, ⁴ , M. A. Fletcher² ^, ⁴

¹Department of Psychiatry
²Center for the Biopsychosocial Study of AIDS
³Department of Psychology
⁴Department of Medicine
⁵Exercise Sciences and Sport Studies, University of Miami, Miami, Florida, USA

Abstract

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Abstract

This study was conducted to determine the effects of an aerobic exercise training program on subpopulations of lymphocyte phenotypes. Fourteen healthy but sedentary males, 18-40 years of age, were randomly assigned to either an aerobic exercise training or control condition. Aerobic exercise training consisted of three 45-minute sessions of cycle ergometry exercise per week at 70-80% of age-predicted maximum heart rate for ten weeks. The aerobic exercise training resulted in a significant decrease in submaximal heart rate from 176 to 150 beats per minute to a fixed work rate of 150 watts (p<.01). This training effect was accompanied by increases in the resting level of the following lymphocyte subpopulations: CD2 (1717 vs 2183 mm³; p<.01), CD4 (942 vs 1280mm³; p<.01), CD45RA+CD4+ (312 vs 595mm³; p<.01), CD8 (655 vs 816mm³; p<.05), and CD20 (162 vs 244mm³; p<.01) cell counts. These findings indicate that several lymphocyte subpopulations are increased following a 10-week program of aerobic exercise training.

Key words

Aerobic training - exercise - immune system - lymphocyte phenotypes

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