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Horm Metab Res 2008; 40(2): 99-107
DOI: 10.1055/s-2007-1022561
Review

© Georg Thieme Verlag KG Stuttgart · New York

Dendritic Cell Subtypes and In Vitro Generation of Dendritic Cells

B. Jacobs 1 , M. Wuttke 1 , C. Papewalis 1 , J. Seissler 2 , M. Schott 1
  • 1Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
  • 2Medical Clinic Innensadt, Ludwig-Maximilians-University Muenchen, Muenchen, Germany
Further Information

Publication History

received 15.10.2007

accepted 26.11.2007

Publication Date:
19 February 2008 (online)

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Abstract

Dendritic cells (DCs) are highly potent antigen-presenting cells crucial for the innate and adaptive immune response and for maintaining immune tolerance towards self-antigens. Although they share many common features, multiple DC subtypes with different immune functions have been identified. Originally, DCs were considered to be cells with purely myeloid origin. Recent studies have now demonstrated that DCs can also develop from lymphatic progenitors. Various cytokines and transcription factors are known to be responsible for the development of DC subpopulation. Depending on the subpopulation and the maturation state of these cells, they are either able to induce a broad cytotoxic immune response, and therefore represent a promising tool for anticancer vaccination therapies in humans or induce immune tolerance and are important within the context of autoimmunity. This review will focus on recent advances on the identification of different DC subpopulations including phenotypical and functional differences and on recent developments on protocols for in vitro generation of myeloid-derived DCs.

Key words

dendritic cells - subtypes - in vitro generation - myeloid dendritic cells - plasmocytoid dendritic cells - immunity

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Correspondence

M. SchottMD 

Department of Endocrinology

Diabetology and Rheumatology

University Hospital Duesseldorf

Moorenstr. 5

40225 Duesseldorf

Germany

Phone: +49/211/811 78 10

Fax: +49/211/811 78 60

Email: matthias.schott@uni-duesseldorf.de